According to this article over at Wired, DARPA (Defense Advanced Research Projects Agency ... pardon the septic spelling) have come up with a nasal spray called Orexin A that allows one to remain awake for extended periods with none of the usual detrimental side effects.
While I don't sleep a huge amount as it is, I'm sure this stuff also helps maintain alertness, which would definitely be welcome during those long sessions of hacking code ... or watching entire seasons of QI in a single sitting :-).
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