He's a university computer science lecturer who has pancreatic cancer and at the time of writing is estimated to have less than six months to live.
This is another lecture he gave, on time management. The topic may sound a little dry, but in case you've not seen him before, he's an excellent speaker. Funny, witty expressive, but to the point.
Definitely worth watching. As Life Hacker said, you may want to skip forward to around the twelve minute mark, if you're short on time.
Randy's "Last Lecture".